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J Med Microbiol. 2004 Aug;53(Pt 8):813-7.

Genetic diversity of the dnaJ gene in the Mycobacterium avium complex.

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Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Gunma, Japan.


The Mycobacterium avium complex (MAC) is associated with various diseases in humans as a zoonosis. The dnaJ gene was partially sequenced in Schaefer's 28 reference strains of MAC, 14 human MAC isolates and 22 veterinary isolates. From substitutions affecting 21-32 nucleotides, all strains could be classified into 14 groups. Most nucleotide substitutions did not alter amino acid sequences. Approximately 8 % genetic diversity was seen in these strains, which divided into two clusters: cluster I (0.8 % genetic diversity), comprising the reference strain serotypes 1-6, 8-11 and 21 and all isolates; and cluster II (7 % genetic diversity), comprising the remaining reference strains. Analysis of the dnaJ gene in MAC may be useful in epidemiological studies.

[Indexed for MEDLINE]

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