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Trends Neurosci. 2004 Aug;27(8):447-52.

Milestones of neuronal development in the adult hippocampus.

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VolkswagenStiftung Research Group, Department of Experimental Neurology, Charité University Medicine Berlin, Schumannstrasse 20/21, 10117 Berlin, Germany.


Adult hippocampal neurogenesis originates from precursor cells in the adult dentate gyrus and results in new granule cell neurons. We propose a model of the development that takes place between these two fixed points and identify several developmental milestones. From a presumably bipotent radial-glia-like stem cell (type-1 cell) with astrocytic properties, development progresses over at least two stages of amplifying lineage-determined progenitor cells (type-2 and type-3 cells) to early postmitotic and to mature neurons. The selection process, during which new neurons are recruited into function, and other regulatory influences differentially affect the different stages of development.

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