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Chem Biol. 2004 Jul;11(7):889-91.

Mapping key elements of a protein motif.

Author information

  • 1Program in Gene Function and Expression, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Abstract

In this issue of Chemistry & Biology, Weiss and colleagues use phage display to map residues in the engrailed homeodomain that influence DNA recognition. Their shotgun scanning data provides surprising new insights into the importance of regions outside the recognition helix and N-terminal arm for DNA binding.

PMID:
15271344
DOI:
10.1016/j.chembiol.2004.07.005
[PubMed - indexed for MEDLINE]
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