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Immunology. 2004 Aug;112(4):521-30.

The potential for Toll-like receptors to collaborate with other innate immune receptors.

Author information

1
Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK.

Abstract

Cells of the innate immune system express a large repertoire of germ-line encoded cell-surface glycoprotein receptors including Toll-like receptors (TLRs). TLRs recognize conserved motifs on microbes and induce inflammatory signals. Evidence suggests that individual members of the TLR family or other non-TLR surface antigens either physically or functionally interact with each other and cumulative effects of these interactions instruct the nature and outcome of the immune response to a particular pathogen.

PMID:
15270722
PMCID:
PMC1782521
DOI:
10.1111/j.1365-2567.2004.01941.x
[Indexed for MEDLINE]
Free PMC Article

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