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Curr Biol. 2004 Jul 27;14(14):R562-4.

TCR signaling: another Abl-bodied kinase joins the cascade.

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1
Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH, Gerontology Research Center, Baltimore, Maryland 21224-6825, USA. WangeR@grc.nia.nih.gov

Abstract

Protein tyrosine kinases have long been recognized as the most proximal actors in T-cell antigen receptor (TCR) signaling. Three non-receptor tyrosine kinase families (Src, ZAP-70 and Tec) are known to be critical, but a new study now shows that room needs to be made in this pathway for yet another protein tyrosine kinase family - Abl/Arg.

PMID:
15268875
DOI:
10.1016/j.cub.2004.07.012
[Indexed for MEDLINE]
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