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FEMS Microbiol Lett. 1992 Aug 15;74(2-3):195-9.

Imipenem resistance in Enterobacter aerogenes is associated with derepression of chromosomal cephalosporinases and impaired permeability.

Author information

1
Department of Bacteriology, Hellenic Pasteur Institute, Athens University, Greece.

Abstract

Enterobacter aerogenes mutants with high-level resistance to imipenem were studied. They were derived from strains characterized by stable over-production of a class-I beta-lactamase. This enzyme (pI = 8.2) exhibited high affinity toward imipenem and hydrolysed the drug slowly. Imipenem-resistant mutants lacked a major 43-kDa outer membrane protein and displayed decreased permeability to cephaloridine. Introduction of a plasmid coding for the regulatory ampD gene abolished beta-lactamase production and rendered the mutants susceptible to imipenem.

PMID:
1526451
DOI:
10.1016/0378-1097(92)90428-q
[Indexed for MEDLINE]

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