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Arch Neurol. 2004 Jul;61(7):1104-7.

Frontal assessment battery and differential diagnosis of frontotemporal dementia and Alzheimer disease.

Author information

1
Institut National de la Santé et de la Récherche Médicale E 007 and Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France. aslachevsky@adsl.tie.cl

Abstract

BACKGROUND:

The different distribution of pathologic features in frontotemporal dementia (FTD) and Alzheimer disease (AD) predicts a predominant dysexecutive syndrome in FTD. The Frontal Assessment Battery (FAB) has previously been validated in diseases associated with a frontal lobe dysfunction.

OBJECTIVE:

To evaluate the sensitivity of the FAB to differentiate FTD and AD.

DESIGN:

Comparison study.

SETTING:

Memory Clinic of the Salpêtrière Hospital, Paris, France.

PATIENTS:

Twenty-six patients with FTD and 64 patients with AD.

MAIN OUTCOME MEASURES:

Comparison of FAB and Mini-Mental State Examination (MMSE) scores between patients with FTD and those with AD.

RESULTS:

The mean +/- SD FAB scores significantly differed between patients with FTD (7.6 +/- 4.2) and those with AD (12.6 +/- 3.7) (P<.001), but not MMSE scores. The FAB correctly identified 78.9% of the patients. These results were maintained in a subgroup of mildly demented patients (MMSE score, > or =24). In these patients, a cutoff score of 12 on the FAB was optimal to differentiate both disorders (sensitivity, 77%; specificity, 87%).

CONCLUSIONS:

The FAB takes less than 10 minutes to administer and provides an objective measure to distinguish FTD from AD in mildly demented patients.

PMID:
15262742
DOI:
10.1001/archneur.61.7.1104
[Indexed for MEDLINE]

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