Abstract
The responses of spinothalamic, spinoreticular, and unidentified spinal neurons to intracardiac administration of phenylbiguanide, a 5-HT3 receptor agonist, were examined in anesthetized cats and monkeys. Eighteen neurons were excited, 5 were inhibited, and 12 were unresponsive to this stimulus. Results suggest that cardiac sympathetic afferents mediate the excitatory responses produced by phenylbiguanide, because bilateral cervical vagotomy failed to block these responses, and aortic injections of phenylbiguanide had little effect on cell activity.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adrenergic Fibers / drug effects*
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Adrenergic Fibers / physiology
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Animals
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Biguanides / administration & dosage
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Biguanides / pharmacology*
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Blood Pressure / drug effects
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Cats
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Heart / drug effects
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Heart / innervation*
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Macaca fascicularis
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Neural Pathways / drug effects
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Neurons, Afferent / drug effects*
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Neurons, Afferent / physiology
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Receptors, Serotonin / drug effects
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Spinal Nerves / drug effects*
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Spinal Nerves / physiology
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Vagotomy
Substances
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Biguanides
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Receptors, Serotonin
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phenyl biguanide