Format

Send to

Choose Destination
Curr Opin Cell Biol. 2004 Aug;16(4):392-9.

Cargo recognition during clathrin-mediated endocytosis: a team effort.

Author information

1
Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA. alexander.sorkin@uchsc.edu

Abstract

Transmembrane proteins destined to endosomes are selectively accumulated in clathrin-coated pits at the plasma membrane and rapidly internalized in clathrin-coated vesicles. The recognition of specific sequence motifs in transmembrane cargo by coated-pit proteins confers specificity on the endocytic process. Interaction of membrane cargo with the clathrin adaptor protein complex AP-2 is the major mechanism of cargo sorting into coated pits in mammalian cells. Recent studies have revealed a variety of alternative mechanisms of cargo recruitment involving additional adaptor proteins. These alternative mechanisms appear to be particularly important during clathrin-mediated endocytosis of signaling receptors.

PMID:
15261671
DOI:
10.1016/j.ceb.2004.06.001
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center