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Cell. 2004 Jul 23;118(2):145-8.

Polycystins: from mechanosensation to gene regulation.

Author information

1
Laboratoire de Neurophysiologie Cellulaire, CNRS-UMR 6150, Faculté de Médecine, IFR Jean Roche, Bd. Pierre Dramard, 13916 Marseille Cedex 20, France. delmas.p@jean-roche.univ-mrs.fr

Abstract

Polycystin proteins have been suggested to form mechanosensory transduction complexes involved in a variety of biological functions including sperm fertilization, mating behavior, and asymmetric gene expression in different species. Furthermore, their dysfunction is the cause of cyst formation in human kidney disease. This review focuses on the pros and cons of their candidacy as mechanically gated channels and on recent findings that have significantly advanced our physiological insight.

PMID:
15260985
DOI:
10.1016/j.cell.2004.07.007
[Indexed for MEDLINE]
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