Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Eye Res. 2004 Apr;28(4):241-50.

A new paradigm for corneal wound healing research: the white leghorn chicken (Gallus gallus domesticus).

Author information

1
Department of Ophthalmology and Free Electron Laser Laboratory, Duke University Center, Durham, NC 27710, USA.

Abstract

PURPOSE:

To evaluate the chicken cornea as a model for corneal wound healing research.

METHODS:

We conducted studies on normal chicken corneas and on corneas following mechanical debridement and photorefractive keratectomy (PRK).

RESULTS:

The chicken cornea possesses six distinct layers that resemble the layers of the human cornea, including a substantial Bowman's layer measuring 5.2 +/- 0.3 microm thick. Reepithelialization time was 44.8 +/- 1.1 hours with a sliding rate of 75.3 +/- 3.2 microm/hour following mechanical debridement and 54.4 +/- 2.8 hours with a sliding rate of 63.3 +/- 3.2 microm/hour for PRK-treated corneas. Biomicroscopic haze post-PRK peaked at 4-6 weeks and regressed until 20 weeks post-PRK. Histologic and clinical observations of wound healing strongly paralleled that noted in humans.

CONCLUSION:

The chicken cornea's morphology and wound healing response render it a useful model for corneal wound healing investigations.

PMID:
15259293
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center