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J Cell Biochem. 2004 Aug 1;92(5):869-81.

Metabolic pathways and physiological and pathological significances of lysolipid phosphate mediators.

Author information

1
Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770-8505, Japan. tokumura@ph.tokushima-u.ac.jp

Abstract

Lysophosphatidic acid and sphingosine 1-phosphate are structurally simple and physiologically very important lysophospholipids. Because they possess distinct structural backbones (glycerol and sphingosine, respectively), there are different metabolic pathways for their intracellular production. Recently, several key enzymes that produce or degrade these lysolipid phosphate mediators extracellularly have been characterized. This review focuses on the physiological and pathophysiological significances of the extracellular metabolic pathways involving recently characterized exo-type lysophospholipase D, ecto-type phospholipase A, and ecto-type lipid phosphate phosphatase.

PMID:
15258912
DOI:
10.1002/jcb.20147
[Indexed for MEDLINE]

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