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Nat Struct Mol Biol. 2004 Aug;11(8):797-8. Epub 2004 Jul 18.

Clostridium perfringens epsilon-toxin shows structural similarity to the pore-forming toxin aerolysin.

Author information

1
Department of Crystallography, Birkbeck College, Malet Street, London WC1E 7HX, UK.

Abstract

Epsilon-toxin from Clostridium perfringens is a lethal toxin. Recent studies suggest that the toxin acts via an unusually potent pore-forming mechanism. Here we report the crystal structure of epsilon-toxin, which reveals structural similarity to aerolysin from Aeromonas hydrophila. Pore-forming toxins can change conformation between soluble and transmembrane states. By comparing the two toxins, we have identified regions important for this transformation.

PMID:
15258571
DOI:
10.1038/nsmb804
[Indexed for MEDLINE]

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