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Brain Res. 1992 Aug 7;587(2):338-42.

Widespread increase of nerve growth factor protein in the rat forebrain after kindling-induced seizures.

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Department of Neurology, University Hospital, Lund, Sweden.


Nerve growth factor (NGF) protein levels were determined in various forebrain regions using a two-site immunoassay following kindling-induced seizures. In the dentate gyrus the NGF content was significantly elevated 7 days after the last seizure (to 152% of control). In the piriform and parietal cortices, maximal increases were seen at 12 h (to 261% of control) and at 24 h (to 169% of control), respectively, and the NGF content was then normalized at 7 days. The increased production of NGF might be a protective response or could be involved in plastic changes underlying kindling epileptogenesis.

[Indexed for MEDLINE]

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