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Clin Chim Acta. 2004 Aug 16;346(2):205-9.

Free radical toxicity and antioxidants in Guillain-Barre syndrome, a preliminary study.

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1
Department of Biochemistry, Kasturba Medical College and Hospital, Manipal-576 104, Karnataka, India.

Abstract

BACKGROUND:

The generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of a vast array of disease processes including some neurological disorders.

METHOD:

Ten patients with Guillain-Barre syndrome (GBS) and 10 age and sex-matched controls were included in this study. The erythrocyte glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA) levels, as well as plasma antioxidant vitamins C and E and serum glutathione-S-transferase (GST) levels were estimated spectrophotometrically.

RESULTS:

The plasma vitamin E and the serum total glutathione-S-transferase levels were markedly increased in both pre- and post-treated cases of GBS when compared to controls. The erythrocyte glutathione and malondialdehyde levels were significantly reduced in GBS cases when compared to normals. However, plasma vitamin C and erythrocyte superoxide dismutase were not altered when compared to controls.

CONCLUSION:

Free radical toxicity may have an influence in patients suffering from GBS.

PMID:
15256322
DOI:
10.1016/j.cccn.2004.03.032
[Indexed for MEDLINE]
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