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Br J Clin Pharmacol. 2004 Aug;58(2):209-11.

In vitro fertilization and childhood retinoblastoma.

Author information

1
The Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, 11 Muzzey Street, Lexington, MA 02421, USA. bdb2@bu.edu

Abstract

AIMS:

To estimate the frequency of childhood retinoblastoma among children conceived by in vitro fertilization (IVF).

METHODS:

Using the United Kingdom-based General Practice Research Database (GPRD), we identified all live births, cases of retinoblastoma and IVF procedures occurring between January 1989 and December 2001.

RESULTS:

We identified 0 cases of retinoblastoma among 176 children conceived by IVF (Risk = 0/176, one-sided 97.5% CI 0, 0.02) and 24 cases of retinoblastoma diagnosed before age 5 years among 358,094 children not conceived by IVF (6.7 cases per 100,000 births [95% CI 4.5, 10]).

CONCLUSIONS:

These data provide some reassurance that children born as a result of IVF are not at markedly increased risk of retinoblastoma.

Comment in

PMID:
15255804
PMCID:
PMC1884583
DOI:
10.1111/j.1365-2125.2004.02109.x
[Indexed for MEDLINE]
Free PMC Article

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