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Annu Rev Biomed Eng. 2004;6:303-29.

Functional efficacy of tendon repair processes.

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  • 1Department of Biomedical Engineering, Noyes-Giannestras Biomechanics Laboratory, University of Cincinnati, Cincinnati, Ohio 45221-0048, USA.


Despite various attempts to repair and replace injured tendon, an understanding of the repair processes and a systematic approach to achieving functional efficacy remain elusive. In this review the epidemiology of tendon injury and repair is first examined. Using a traditional paradigm for repair assessment, the biology and biomechanics of normal tendon, natural healing, and repair are then explored. New treatment strategies such as functional tissue engineering are discussed, including a functional approach to treatment that involves the development of in vivo functional design parameters to judge the acceptability of a repair outcome. The paper concludes with future directions.

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