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Annu Rev Biomed Eng. 2004;6:209-28.

Optical projection tomography.

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1
MRC Human Genetics Unit, Western General Hospital, Crewe Road South, EH4 2XU, United Kingdom. James.Sharpe@hgu.mrc.ac.uk

Abstract

Optical projection tomography is a new approach for three-dimensional (3-D) imaging of small biological specimens. It fills an imaging gap between MRI and confocal microscopy, being most suited to specimens that are from 1 to 10 mm across. The tomographic principles of optical projection tomography (OPT) are explained, its most important applications in biomedical research explored, and comparisons drawn of its pros and cons compared to a number of alternative imaging technologies.

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