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Org Lett. 2004 Jul 22;6(15):2635-7.

Boron binding with the quorum sensing signal AI-2 and analogues.

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  • 1Departments of Chemistry and Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.

Abstract

[reaction: see text] The unstable bacterial metabolic product, DPD, and the related natural product, laurencione, are shown to have a high affinity for borate complexation, through the hydrated analogue. The boron complex of DPD is Vibrio harveyi AI-2, an interspecies quorum sensing signal in bacteria, and an affinity column with a borate resin is effective in providing the first method for concentrating and purifying V. harveyi AI-2 from the biosynthetic product.

PMID:
15255709
DOI:
10.1021/ol048976u
[PubMed - indexed for MEDLINE]
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