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Int J Vitam Nutr Res. 2004 Mar;74(2):144-6.

Nutrient supplementation as adjunct therapy in pulmonary tuberculosis.

Author information

1
Allergy, Asthma and Immunology Centre, Y-182 Regency Park II, DLF Phase IV, Gurgaon 122002, India. nutres2002@yahoo.com

Abstract

The study examined the effect of supplementation with multivitamins and trace elements on microbiological and radiological recovery in patients with pulmonary tuberculosis. Forty-four patients aged 28-50 years were diagnosed with active pulmonary tuberculosis based on X-ray of the chest and smear examination of the sputum for the presence of acid-fast bacilli. They were all treated for six months with a standard anti-tuberculosis regimen that has been found to be effective worldwide for disease control. The subjects were randomized to receive either a multivitamin-trace element supplement or a placebo containing calcium. The two groups were matched on all relevant confounding variables. At two months into the treatment, the group that was supplemented with a multivitamin-trace element preparation showed a significant reduction in the number of individuals with sputum smear positive for acid-fast bacillus: two out of 22 individuals, compared with seven out of 22 among placebo-treated controls (p = 0.028, Fisher's test). It is concluded that patients with tuberculosis should be supplemented with a suitable micronutrient preparation that contains optimum amounts of all vitamins and trace elements that have been documented to enhance the immune response.

PMID:
15255451
DOI:
10.1024/0300-9831.74.2.144
[Indexed for MEDLINE]
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