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Org Biomol Chem. 2004 Jul 21;2(14):1965-6. Epub 2004 Jun 22.

A new environment-sensitive fluorescent amino acid for Fmoc-based solid phase peptide synthesis.

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1
Departments of Chemistry and Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

Abstract

A new 4-(N,N-dimethylamino) phthalimide-based environment-sensitive fluorescent building block for solid phase peptide synthesis, has been synthesized and incorporated into peptides. Peptides incorporating this residue show great potential for biological applications in sensing protein/protein interactions.

PMID:
15254619
DOI:
10.1039/b408001g
[Indexed for MEDLINE]
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