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Cell Cycle. 2004 Jul;3(7):895-9. Epub 2004 Jul 2.

Dynamics in the p53-Mdm2 ubiquitination pathway.

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Institute for Cancer Genetics and Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.


The tumor suppressor p53 is highly regulated under various states of cellular stress. p53 stability is predominantly regulated through the ubiquitin-proteasomal pathway by the E3 ligase Mdm2. p53 ubiquitination is a dynamic process with Mdm2 capable of catalyzing both mono- and polyubiquitination. Additionally, deubiquitination is an important step occurring in p53 and Mdm2 stabilities. Factors such as HAUSP, p14(ARF), and MdmX play important regulatory roles in p53 ubiquitination/deubiquitination and their interplay with Mdm2 and p53 compound layers of complexity for regulating this important pathway.

[Indexed for MEDLINE]

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