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Endocr Pract. 1999 Jan-Feb;5(1):33-6.

Severe hypertriglyceridemia and acute pancreatitis during pregnancy: treatment with gemfibrozil.

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  • 1Department of Endocrinology, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Abstract

OBJECTIVE:

To describe the effect of gemfibrozil therapy during pregnancy in a woman with severe hypertriglyceridemia.

METHODS:

We present a case report, with details of lipid levels throughout several attempted pregnancies, and discuss other similar published studies.

RESULTS:

In a 22-year-old woman, severe acute pancreatitis due to hypertriglyceridemia developed during her first pregnancy. After a prolonged hospital course, the outcome was fetal demise. The patient was subsequently treated with gemfibrozil, which controlled the hypertriglyceridemia. A second pregnancy ended with a therapeutic abortion at 1 month because of the possible risk of pancreatitis. Gemfibrozil therapy was instituted but subsequently discontinued when she was discovered to be pregnant again, at approximately 10 weeks of gestation; the potential risks involved with the use of this drug during pregnancy were unknown. Because of the patient's strong desire to maintain the pregnancy, gemfibrozil treatment was resumed 1 week later in order to help prevent recurrent pancreatitis. The patient ultimately delivered a fullterm healthy boy, and she had no recurrence of pancreatitis or other complications.

CONCLUSION:

In selected patients at high risk for pancreatitis, the potential risk of gemfibrozil use during pregnancy may be offset by its benefits in the management of severe hypertriglyceridemia.

PMID:
15251700
DOI:
10.4158/EP.5.1.33
[PubMed]
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