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J Oral Pathol Med. 2004 Aug;33(7):398-404.

Cytologic and DNA-cytometric very early diagnosis of oral cancer.

Author information

1
Department of Oral Surgery, Heinrich Heine University, Duesseldorf, Germany. dimitra.m@tiscali.de

Abstract

BACKGROUND:

The aim of this study was to evaluate the diagnostic accuracy of exfoliative cytology (EC) and DNA-image cytometry applied to suspicious oral lesions compared with synchronous histology.

METHODS:

Brush- and scalpel biopsies were obtained from 98 patients with suspicious oral lesions. In cases, in which EC revealed malignant or suspicious cells, nuclear DNA-contents were measured using a TV image analysis system.

RESULTS:

Among 98 oral lesions both cytological and histological diagnosis showed no sign of malignancy or dysplasia in 75. In 23 cases cytology yielded tumor cell-positive (15), suspicious (four) or doubtful (four) results. DNA-cytometry showed aneuploidy in 19 of these. The comparison between cytological diagnosis combined with DNA-cytometry and biopsy-histology resulted in a sensitivity of 100% and a specificity of 97.4%.

CONCLUSION:

In conclusion, cytology with DNA-cytometry is a highly sensitive, specific and non-invasive method for the early diagnosis of oral epithelial neoplasia, showing excellent compliance among patients.

PMID:
15250831
DOI:
10.1111/j.1600-0714.2004.0235.x
[Indexed for MEDLINE]

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