The spontaneous hydrolysis of phosphate ester monoanions is relatively easy, but the reaction of water with simple phosphate ester dianion appears to be the slowest biomimetic reaction whose spontaneous rate has been measured in water, with an estimated half time of approximately 1012 years at room temperature in the absence of a catalyst. Here, we report an alternative mode of cleavage of methyl phosphate that involves hydroxide attack at the carbon atom of methyl phosphate and proceeds at a rate proportional to the square of the concentration of lithium hydroxide.