Format

Send to

Choose Destination
J Steroid Biochem Mol Biol. 1992 Sep;43(1-3):69-78.

Growth factors in breast cancer: mitogenesis to transformation.

Author information

1
Lombardi Cancer Research Center, Georgetown University, Washington, DC 20007.

Abstract

While endocrine steroid hormones have been known for many years to regulate normal and malignant mammary epithelium, recent studies have led to an appreciation of polypeptide growth factors as locally-acting autocrine and paracrine effectors. In the current article we summarize what is known about growth factor regulation and action in the normal mammary gland and about perturbations of the steroid-growth factor interplay as cancer progresses. A major theme is that oncogenic activation modulates both regulation of production and function of growth factors in the mammary gland.

PMID:
1525068
DOI:
10.1016/0960-0760(92)90189-p
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center