Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population

S Helisalmi; B Dermaut; M Hiltunen; A Mannermaa; M Van den Broeck; M Lehtovirta; A M Koivisto; S Iivonen; M Cruts; H Soininen; C Van Broeckhoven

doi:10.1212/01.wnl.0000133153.98139.4e

Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population

Neurology. 2004 Jul 13;63(1):173-5. doi: 10.1212/01.wnl.0000133153.98139.4e.

Authors

S Helisalmi¹, B Dermaut, M Hiltunen, A Mannermaa, M Van den Broeck, M Lehtovirta, A M Koivisto, S Iivonen, M Cruts, H Soininen, C Van Broeckhoven

Affiliation

¹ Department of Neuroscience, Kuopio University Hospital and University of Kuopio, Finland.

PMID: 15249634
DOI: 10.1212/01.wnl.0000133153.98139.4e

Abstract

The authors previously reported that genetic variation in the gene coding for nicastrin (NCSTN) modified risk for familial early-onset Alzheimer disease (AD) in a Dutch population-based sample. Risk was highest in patients without an APOE epsilon4 allele. Here, they evaluated if NCSTN polymorphisms increased risk of AD in the eastern Finnish population. A significant difference in one haplotype was observed in AD patients without the APOE epsilon4 allele.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Alzheimer Disease / epidemiology
Alzheimer Disease / genetics*
Amyloid Precursor Protein Secretases
Apolipoproteins E / genetics
Female
Finland / epidemiology
Genes, Dominant
Genetic Predisposition to Disease
Genotype
Haplotypes / genetics
Humans
Male
Membrane Glycoproteins / genetics*
Membrane Proteins / genetics
Middle Aged
Polymorphism, Single Nucleotide*
Presenilin-1
Presenilin-2

Substances

Apolipoproteins E
Membrane Glycoproteins
Membrane Proteins
PSEN1 protein, human
PSEN2 protein, human
Presenilin-1
Presenilin-2
nicastrin protein
Amyloid Precursor Protein Secretases