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Am J Geriatr Psychiatry. 2004 Jul-Aug;12(4):437-9.

Lower mortality in geriatric patients receiving risperidone and olanzapine versus haloperidol: preliminary analysis of retrospective data.

Author information

1
Department of Psychiatry, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, OH 45267-0559, USA. henry.nasrallah@uc.edu

Abstract

OBJECTIVE:

The authors examined the mortality rate in geriatric patients receiving either haloperidol or atypical antipsychotics.

METHODS:

Authors tracked mortality over a 2-year period in patients age 65 years or older receiving haloperidol (N=299) or the atypical antipsychotics risperidone or olanzapine (N= 1,254).

RESULTS:

Sixty-four patients in the haloperidol group (21.4%) and 61 patients in the atypical group (4.75%) died during the 2-year study period. The difference was statistically significant.

CONCLUSIONS:

The findings suggest that mortality in elderly patients receiving haloperidol is significantly higher than in those receiving the atypical antipsychotics risperidone or olanzapine. Authors discuss possible causal mechanisms.

PMID:
15249282
DOI:
10.1176/appi.ajgp.12.4.437
[Indexed for MEDLINE]
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