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Ai Zheng. 2004 Jul;23(7):767-70.

[Epidemiological study of nasopharyngeal carcinoma risk in relatives of high-risk families in Guangdong].

[Article in Chinese]

Author information

1
Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P.R.China.

Abstract

BACKGROUND & OBJECTIVE:

Familial clustering of NPC has been widely observed, however, related investigations were mainly involved in individual reports for high-risk families or case-control study with small sample size, so no quantitive evaluation for NPC risk in relatives of high-risk families documented in high-risk area until now. The purpose of the study was to estimate NPC risk among relatives of high-risk pedigrees in Guangong province, so as to provide information for genetic epidemiology and clinical genetic consultation.

METHODS:

One hundred and thirteen high-risk pedigrees were collected in the Cancer Center of Sun Yat-sen University, and standardized incidence ratio (SIR) was used to estimate NPC risk of first degree relatives (FDR).

RESULTS:

NPC risk was significantly higher in first degree relatives that in general population, and SIR was 37.55; in addition, SIRs were 50.72, 79.64, 7.12, and 33.58 in their brothers, sisters, fathers, and mothers respectively.

CONCLUSION:

NPC risk of relatives in familial NPC pedigrees elevates 7.12 to 79.64 times in high-risk families.

PMID:
15248909
[Indexed for MEDLINE]

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