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Neuron. 1992 Sep;9(3):405-16.

Local increases in intracellular calcium elicit local filopodial responses in Helisoma neuronal growth cones.

Author information

1
Department of Anatomy and Neurobiology, Colorado State University, Fort Collins 80523.

Abstract

Highly localized changes in intracellular Ca2+ concentration ([Ca2+]i) can be evoked in neuronal growth cones; these are followed by local changes in filopodia. Focally applied electric fields evoked spatially restricted, high magnitude increases in growth cone [Ca2+]i. The earliest and greatest increases were localized to small regions within a growth cone. Such fields also produced characteristic changes in the disposition of filopodia: both filopodial length and number were significantly increased on the cathode side of growth cones. The requirement for extracellular Ca2+ and the strong correlation between the evoked rise in [Ca2+]i and the changes in filopodia (r = 0.98) indicate that cathode stimulation results in local Ca2+ influx, leading to locally increased [Ca2+]i and local changes in filopodial behavior.

PMID:
1524824
DOI:
10.1016/0896-6273(92)90179-h
[Indexed for MEDLINE]

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