Format

Send to

Choose Destination
Nat Immunol. 2004 Aug;5(8):809-17. Epub 2004 Jul 11.

CD8+ T cell contraction is controlled by early inflammation.

Author information

1
Department of Microbiology, University of Iowa, Iowa City, Iowa, USA.

Abstract

Pathogen-specific CD8(+) T cells expand in number after infection and then their numbers invariably contract by 90-95%, leaving a stable memory cell pool. The chief features of this response are programmed early after infection; however, the factors regulating contraction are mostly undefined. Here we show that antibiotic treatment before Listeria monocytogenes infection induced numbers of protective memory CD8(+) T cells similar to those in control infected mice, by a pathway without contraction. The absence of contraction correlated with decreased early inflammation and interferon-gamma production and an increased fraction of CD8(+) T cells expressing the interleukin 7 receptor at the peak of the response. Thus, contraction is controlled by early inflammation but is not essential for the generation of protective memory CD8(+) T cells after infection.

PMID:
15247915
DOI:
10.1038/ni1098
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center