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Nat Med. 2004 Aug;10(8):811-3. Epub 2004 Jul 11.

A role for Streptococcus pneumoniae in virus-associated pneumonia.

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1
University of the Witwatersrand/Medical Research Council/National Institute for Communicable Diseases Respiratory and Meningeal Pathogens Research Unit, Atlanta 30332, USA.

Abstract

Here we show, in a double-blind, randomized, placebo-controlled trial in 37,107 fully immunized infants in Soweto, South Africa, that a 9-valent pneumococcal conjugate vaccine, PncCV, prevents 31% (95% confidence interval = 15-43%) of pneumonias associated with any of seven respiratory viruses in children in hospital. These data suggest that the pneumococcus has a major role in the development of pneumonia associated with these viruses and that viruses contribute to the pathogenesis of bacterial pneumonia.

PMID:
15247911
DOI:
10.1038/nm1077
[Indexed for MEDLINE]
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