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Pediatr Infect Dis J. 2004 Jul;23(7):687-8.

Resistant Candida parapsilosis associated with long term fluconazole prophylaxis in an animal model.

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Department of Medicine and Physiology, Southwest Foundation for Biomedical Research, University of Texas Health Science Center, San Antonio, Texas, USA.


We report an increased occurrence of fluconazole-resistant Candida parapsilosis after a 4-year period of antifungal prophylaxis in a premature animal neonatal intensive care unit. Although prevention of nosocomial fungal infections in premature infants is desirable, implementation of fluconazole prophylaxis should be undertaken with caution. Where such programs are in place, evaluation of fungal isolates for drug resistance should be considered.

[Indexed for MEDLINE]

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