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Ann N Y Acad Sci. 2004 Jun;1019:506-8.

Testing the free radical theory of aging in bats.

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1
Department of Ecology, Evolution and Behavior, University of Minnesota, 1987 Upper Buford Circle, Saint Paul, MN 55108, USA. anja.brunet@stanfordalumni.org

Abstract

The extended longevity of bats, despite their high metabolic rates, may provide insight to patterns and mechanisms of aging. I tested the free radical theory of aging as an explanation for the extreme longevity of the little brown bat, Myotis lucifugus (maximum life span potential [MLSP] = 34 years). In a comparative study, I measured whole-organism oxygen consumption and mitochondrial hydrogen peroxide production in brain, heart, and kidney tissues from M. lucifugus and short-tailed shrews, Blarina brevicauda (MLSP = 2 years). As predicted by the free radical theory of aging, M. lucifugus produced approximately half the amount of hydrogen peroxide as B. brevicauda. In addition, I compared oxygen consumption and hydrogen peroxide production of adult (approximately 1 year) and juvenile (fully developed and fledged young of the year) M. lucifugus to assess oxidative damage to mitochondria (measured as an increase in hydrogen peroxide production) due to the high metabolic rate associated with flight. Contrary to my prediction, juveniles had significantly higher levels of hydrogen peroxide production than adults. I propose that the decreased free radical production in adults is the result of within-individual selection of efficient mitochondria due to selective pressure created by the high energetic demands of flight.

PMID:
15247075
DOI:
10.1196/annals.1297.093
[Indexed for MEDLINE]
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