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Biochim Biophys Acta. 2004 Jul 5;1692(2-3):145-57.

Regulation of Bcl-2 proteins during anoikis and amorphosis.

Author information

1
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur-NRB 356, Boston, MA 02115, USA. smartin@genetics.med.harvard.edu

Abstract

Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Numerous signaling pathways converge to affect the levels and posttranslational modifications of Bcl-2 family proteins. Recent work has defined specific roles for different Bcl-2 proteins in the disruption of mitochondrial function that leads to cell death. Using this understanding of Bcl-2 protein function as a framework, we will consider the molecular mechanisms of apoptosis induced by integrin detachment (anoikis) and cell death stimulated by the loss of cytoskeletal architecture (amorphosis).

PMID:
15246684
DOI:
10.1016/j.bbamcr.2004.02.008
[Indexed for MEDLINE]
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