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Trends Cell Biol. 2004 Jul;14(7):339-41.

Phosphatases join kinases in DNA-damage response pathways.

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1
Department of Hematology and Oncology, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA.

Abstract

An inappropriate imbalance of kinase and phosphatase activities could be deleterious to cellular processes such as proliferation. Cellular responses to DNA damage use signal-transduction pathways involving phosphorylation events, and such modifications must be reversible to make these responses transient, rather than permanent, events. Three recent articles describe roles for two phosphatases in signaling pathways that are activated after DNA damage.

PMID:
15246426
DOI:
10.1016/j.tcb.2004.05.001
[Indexed for MEDLINE]
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