Format

Send to

Choose Destination
J Clin Epidemiol. 2004 Jun;57(6):590-6.

Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbA1c.

Author information

1
Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland. qing.qiao@ktl.fi

Abstract

OBJECTIVE:

To quantify the relative contribution of elevated 2-hr glucose, fasting glucose (FPG), and HbA1c to all-cause mortality.

STUDY DESIGN AND SETTING:

A joint analysis of two prospective studies with baseline glycemia measurements.

RESULTS:

The multivariate adjusted hazard ratios (HRs) corresponding to a one standard deviation increase in HbA1c were 1.14 (95% CI 1.03-1.25), 1.08 (0.98-1.19) for FPG and 1.15 (1.05-1.27) for 2-hr glucose, respectively. Entering the 2-hr glucose to the model based on the FPG and HbA1c significantly improved the prediction of mortality, whereas neither FPG, nor HbA1c added significant information once 2-hr glucose was in the models. In subjects with FPG <7.0 mmol/L and HbA1c < or = 6.5%, the HR was 1.35 (1.03-1.78) in men with 2-hr glucose > or = 7.8 mmol/L compared with men with 2-hr glucose <7.8 mmol/L.

CONCLUSION:

Elevated 2-hr glucose was a predictor of mortality independent of the levels of fasting glucose and HbA1c.

PMID:
15246127
DOI:
10.1016/j.jclinepi.2003.10.007
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center