Send to

Choose Destination
Curr Opin Immunol. 2004 Aug;16(4):511-8.

Mycobacterium leprae-induced demyelination: a model for early nerve degeneration.

Author information

The Rockefeller University, Bronk building, Room 501, 1230 York Avenue, New York, New York 10021, USA.


The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstration of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center