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Curr Opin Immunol. 2004 Aug;16(4):511-8.

Mycobacterium leprae-induced demyelination: a model for early nerve degeneration.

Author information

1
The Rockefeller University, Bronk building, Room 501, 1230 York Avenue, New York, New York 10021, USA. rambuka@imap.rockefeller.edu

Abstract

The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstration of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration.

PMID:
15245748
DOI:
10.1016/j.coi.2004.05.021
[Indexed for MEDLINE]

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