Format

Send to

Choose Destination
Curr Opin Immunol. 2004 Aug;16(4):506-10.

Heat-shock proteins and the host-pathogen interaction during bacterial infection.

Author information

1
Department of Infectious Diseases and Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. g.stewart@imperial.ac.uk

Abstract

Heat-shock proteins (HSPs) are expressed at high levels by bacterial pathogens during adaptation to intracellular survival. Both host and pathogen heat-shock proteins contribute to immunity by receptor-mediated activation of the innate immune response and by participation in the presentation of antigens for the adaptive immune response. Manipulation of these interactions presents a potential route to improved control of infection by vaccination or immunotherapy.

PMID:
15245747
DOI:
10.1016/j.coi.2004.05.007
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center