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Curr Opin Immunol. 2004 Aug;16(4):451-5.

CD8+ T-cell memory: only the good ones last.

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Department of Microbiology, School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104-6076, USA.


Generating long-lasting, protective CD8(+) T-cell memory via vaccination is critical for combating infectious diseases. Advances in the past year have provided many new insights into how memory CD8(+) T cells are generated. It is now recognized that CD8(+) T cells differentiate from 'effector memory' cells into 'central memory' cells, which are stably maintained and confer superior protective immunity. Furthermore, CD4(+) T-cell help plays an important role in guiding the differentiation of CD8(+) T cells into long-lasting, functional memory. These findings have important implications for developing vaccine strategies that induce high-quality CD8(+) T-cell memory, not just high quantity.

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