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Phys Rev Lett. 2004 Jun 4;92(22):220801. Epub 2004 Jun 2.

Tip-enhanced coherent anti-stokes Raman scattering for vibrational nanoimaging.

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Department of Applied Physics, Osaka University, Suita, Osaka 565-0871, Japan.


An electric field enhanced by a metallic nanoprobe has locally induced coherent anti-Stokes Raman scattering (CARS) of adenine molecules in a nanometric DNA network structure. Owing to the third-order nonlinearity, the excitation of the CARS polarization is extremely confined to the end of the tip apex, resulting in a spatial resolution far beyond the diffraction limit of light. Our tip-enhanced CARS microscope visualized the DNA network structure at a specific vibrational frequency (approximately 1337 cm(-1)) corresponding to the ring-breathing mode of diazole of adenine molecules.

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