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Nature. 2004 Jul 8;430(6996):1 p following 165; discussion 2 p following 165.

Physiology: does gut hormone PYY3-36 decrease food intake in rodents?

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  • 1Department of Psychiatry, University of Cincinnati Genome Research Institute, Cincinnati, Ohio 45237, USA.

Erratum in

  • Nature. 2004 Sep 23;431(7007):1038. Withcomb, DC [corrected to Whitcomb, DC].


Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36.

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