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J Clin Microbiol. 2004 Jul;42(7):2898-901.

Bacteremia in an immunocompromised patient caused by a commensal Neisseria meningitidis strain harboring the capsule null locus (cnl).

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1
National Reference Laboratory for Meningococci, Institute for Hygiene and Microbiology, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. uvogel@hygiene.uni-wuerzburg.de

Abstract

We recently described the capsule null locus (cnl) of constitutively unencapsulated Neisseria meningitidis clonal lineages. cnl meningococci were recovered from healthy carriers at high frequency. We here report on the first case of invasive disease caused by cnl meningococci in a severely immunosuppressed patient with chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplantation. The sequence type 845 strain was extensively typed and, furthermore, shown to be sensitive to serum bactericidal activity.

PMID:
15243035
PMCID:
PMC446252
DOI:
10.1128/JCM.42.7.2898-2901.2004
[Indexed for MEDLINE]
Free PMC Article
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