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Am J Physiol Heart Circ Physiol. 2004 Nov;287(5):H1957-66. Epub 2004 Jul 8.

Novel targets of ANG II regulation in mouse heart identified by serial analysis of gene expression.

Author information

1
Dept. of Medicine, Genetics Program, Boston Univ. School of Medicine, 715 Albany St., L-320, Boston, MA 02118, USA. fschw@bu.edu

Abstract

Although the central role of ANG II in cardiovascular homeostasis is well appreciated, the molecular circuitry of its many actions is not completely understood. With the use of serial analysis of gene expression to assess global transcriptional changes in the heart of mice after continuous 7-day ANG II administration, we identified patterns of gene expression indicative of cardiac remodeling, including coordinate regulation of genes previously described in a context of processes associated with hypertrophy and fibrosis. In addition, we discovered several novel ANG II targets, including characterized genes of known function, recently annotated genes of unknown function, and the putative genes not yet present in current databases. The serial analysis of gene expression approach to assess the role of ANG II presented in this report provides new venues for inquiries into ANG II-mediated cardiac function.

PMID:
15242839
DOI:
10.1152/ajpheart.00568.2004
[Indexed for MEDLINE]
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