Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell. 2004 Jul 9;118(1):2-4.

Neddylating the guardian; Mdm2 catalyzed conjugation of Nedd8 to p53.

Author information

1
Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Abstract

The tumor suppressor and transcriptional regulator p53 is perhaps one of the most regulated proteins in the cell nucleus and is acted upon by a variety of protein kinases, acetylases, ubiqutin ligases and hydrolases, and SUMO-conjugating enzymes. Now new work suggests a role for an additional modification-neddylation-in negative regulation of p53 transcriptional activity.

PMID:
15242638
DOI:
10.1016/j.cell.2004.06.015
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center