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Ann N Y Acad Sci. 2004 Jun;1018:533-40.

Oxidative stress to dopaminergic neurons as models of Parkinson's disease.

Author information

1
Institute of Medical Chemistry, Veterinary University of Vienna, Veterinärplatz 1, A-1210 Vienna, Austria.

Abstract

The effects of exogenous toxins (MPP(+), rotenone) and potentially neurotoxic properties of levodopa (L-DOPA) on the survival rate of dopaminergic neurons in dissociated primary culture are presented. Dopamine agonists show a capacity to counteract MPP(+)-toxicity. Moreover, a preserving potential of the antioxidant and bioenergetic coenzyme Q(10) (CoQ(10)) on the activities of tyrosine hydroxylase (TH), complexes I and II of the respiratory chain, and hexokinase activity in striatal slice cultures against MPP(+) is demonstrated.

PMID:
15240412
DOI:
10.1196/annals.1296.066
[Indexed for MEDLINE]

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