The mouse genome is being sequenced in an efficient, coordinated manner. The map is complete and an assembly of whole genome shotgun data is available at a click of the mouse. In the final finished sequence phase, it seems a targeted approach would be more useful than random coverage. There are currently rich pickings available for mouse geneticists--that is to say, as long as their particular region of interest has been covered. Hard lessons learnt from the Human Genome Project have been put into practice, resulting in the elucidation of the mouse genome taking place with greater efficiency. The various genome centres have worked with coordination and a common strategy to generate a draft of the mouse genome in under a year, an achievement that would not have been deemed plausible a few years ago.