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Hepatogastroenterology. 2004 Jul-Aug;51(58):928-30.

Expression of receptor for advanced glycation end products (RAGE) and MMP-9 in human pancreatic cancer cells.

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1
Department of Gastroenterological Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan. moriatsu@med.kobe-u.ac.jp

Abstract

BACKGROUND/AIMS:

Amphoterin is considered as a regulator for the ability of invasion and migration in tumor cells and embryonic neurons through binding to receptor for advanced glycation end products (RAGE), a multiligand cell surface molecule of the immunoglobulin superfamily. As matrix metalloproteinase-9 (MMP-9, gelatinase B) has been reported to play a critical role in tumor progression and metastasis, we have examined the relation of RAGE and MMP in human pancreatic cancer.

METHODOLOGY:

Three representative human pancreatic carcinoma cells were rendered for the study which show different metastatic potential, PANC-1 and MIA PaCa-2 as the cells with high ability, BxPC-3 as with low. The expression of RAGE was examined by RT-PCR. The expression of MMP-9 protein was examined by Western blotting.

RESULTS:

RAGE was strongly expressed in MIA PaCa-2 and PANC-1 that have high metastatic ability. On the contrary, RAGE was expressed little in BxPC-3 that has low ability. Similarly, expression of MMP-9 showed almost the same tendency. RAGE and MMP-9 are expressed concordant with the metastatic ability of the human pancreatic cancer cells.

CONCLUSIONS:

Control of these molecules could be a key to regulating the metastatic ability of pancreatic cancer and this may be exploited in targeted therapy of this cancer.

PMID:
15239215
[Indexed for MEDLINE]
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