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Hepatology. 2004 Jul;40(1):10-5.

Acetaminophen misconceptions.

Author information

1
University of Colorado School of Medicine, Greenwood Village, CO 80121, USA. barry@rumack.com

Abstract

Examination of the pharmacokinetics of acetaminophen can decrease misconceptions involved in clinical evaluation. Enzyme patterns and acetaminophen levels must be related to time and known metabolic phenomena. A careful look at ethanol and nutrition, especially fasting demonstrates that therapeutic doses of acetaminophen do not place patients at a greater risk in either of these instances. An overdose of acetaminophen in a chronic alcohol abuser may result in more severe hepatotoxicity than in the nonalcoholic. CYP2E1 and glutathione must be evaluated simultaneously rather than in isolation. Glucuronidation capacity in humans is not a factor except in massively overdosed patients.

PMID:
15239079
DOI:
10.1002/hep.20300
[Indexed for MEDLINE]

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