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Rheumatology (Oxford). 2004 Oct;43(10):1252-5. Epub 2004 Jul 6.

Remission in rheumatoid arthritis: agreement of the disease activity score (DAS28) with the ARA preliminary remission criteria.

Author information

1
Department of Rheumatology, University Medical Centre Nijmegen, P.O. Box 9101, NL-6500HB Nijmegen, The Netherlands. j.fransen@reuma.umcn.nl

Abstract

OBJECTIVE:

To determine which cut-off point in the RA disease activity score (DAS28) corresponds to fulfilment of the ARA criteria for clinical remission.

METHODS:

The disease activity of patients included in the Nijmegen RA inception cohort was systematically assessed every 3 months. For all visits, a modification of the ARA preliminary criteria for clinical remission was applied and the DAS28 was calculated. Receiver operating characteristic analysis was used to determine the cut-off point with maximum sensitivity and specificity in DAS28 corresponding with fulfilment of the modified ARA criteria.

RESULTS:

Three hundred and seventy-eight patients contributed 4378 visits. In 6.5% of the visits four of the five items and in 1.5% all five items of the modified ARA criteria were fulfilled. The optimal cut-off point for the DAS28 that corresponds to fulfilment of the modified ARA criteria was determined to be 2.66.

CONCLUSION:

DAS28 <2.6 corresponds to fulfilment of the preliminary ARA criteria for clinical remission in RA.

PMID:
15238643
DOI:
10.1093/rheumatology/keh297
[Indexed for MEDLINE]

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